Upregulation of Adenosine Kinase in Rasmussen Encephalitis
نویسندگان
چکیده
منابع مشابه
Upregulation of Adenosine Kinase in Rasmussen Encephalitis
Rasmussen encephalitis (RE) is a rare neurologic disorder of childhood characterized by unihemispheric inflammation, progressive neurologic deficits, and intractable focal epilepsy. The pathogenesis of RE is still enigmatic. Adenosine is a key endogenous signaling molecule with anticonvulsive and anti-inflammatory effects, and our previous work demonstrated that dysfunction of the adenosine kin...
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BACKGROUND Rasmussen encephalitis (RE) is a chronic epileptic disorder of unknown etiology, and is clinically characterized by progressive neurological deterioration, focal seizures often progressing to intractable epilepsy, cognitive decline and hemispheric atrophy. AIMS We report the spectrum of neuropathological changes seen in RE, and discuss the evolutionary mechanisms of this disease. ...
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Rasmussen encephalitis is a chronic, progressive inflammation of the brain of unknown origin. Early diagnosis and treatment with immunoactive agents and/or hemispherectomy are sought to prevent the progressive cognitive decline that accompanies this disease. Combined anatomic and functional neuroimaging may serve to focus the diagnostic workup and to hasten brain biopsy for definitive diagnosis...
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Rasmussen encephalitis (RE) is a rare pediatric neuroinflammatory disease of unknown etiology characterized by intractable seizures, and progressive atrophy usually confined to one cerebral hemisphere. Surgical removal or disconnection of the affected cerebral hemisphere is currently the only intervention that effectively stops the seizures. Histopathological evaluation of resected brain tissue...
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ژورنال
عنوان ژورنال: Journal of Neuropathology & Experimental Neurology
سال: 2013
ISSN: 0022-3069,1554-6578
DOI: 10.1097/01.jnen.0000435369.39388.5c